In the list of 500 most powerful supercomputers , released in November 2008, there are nine Itanium-systems. The most productive of these is the "Columbia" ( eng. Columbia), named in honor of the crew who perished in the crash of the shuttle "Columbia" . it is a 39 point list, established in NASA , contains 13 824 processor cores and has a peak performance of R max = 66.57 tera FLOPS .  "Columbia" was built by SGI of 20 knots SGI Altix 3700 and 4700 and running SUSE Linux Enterprise Server
The main purpose of the "Columbia" is the study of collision processes of spiral galaxies that lead to the formation of elliptical galaxies .
In the edition of June 2009 contained a total of 6 systems based on Itanium. The "Columbia" fell to 58th place.
Itanium architecture supported by world leaders in production servers: Bull , Fujitsu , Fujitsu Siemens Computers , Hitachi , HP , NEC , SGIand Unisys . These vendors have joined the Intel and many software developers to create Itanium Solutions Alliance , to promote architecture and accelerate porting software. Nevertheless, leading manufacturers of servers, but Fujitsu and HP, have little or no interest in developing the market for servers based on Itanium. IBM and Dell have some time to sell systems based on Itanium, do not do more, and not really supporting either 64-bit prefer to sell the chips simpler systems, and a concentration of platforms SPARC and AMD64 Sun has never sold a system based on Itanium.
At the moment, the main sellers of Itanium focused on improving multi-processor servers to work with frequently updated data into critical business and technical applications. Itanium-based systems are often promoted as an open, industry standard alternative to RISC andmainframe -based systems produced by IBM and Sun, while the Itanium processor is designed, manufactured and sold exclusively Intel.Now Itanium-based systems are presented, ranging from 2-processor servers and blade-servers to 512 processors, 128 TB total shared memory.
Itanium is now supported by 10 operating systems including Windows and various distributions of GNU / Linux and UNIX , under which more than 8,000 applications are written for Itanium, and available for work (as at June 2006). Intel says that in the past 12 months the number of available applications has increased by 2 times. Architecture support significantly improved compared to previous years when the shortage was a serious lack of software architecture.